HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Christian Schnell Selected Research

vatalanib (PTK787)

3/2008Inhibition of multiple vascular endothelial growth factor receptors (VEGFR) blocks lymph node metastases but inhibition of VEGFR-2 is sufficient to sensitize tumor cells to platinum-based chemotherapeutics.
6/2006Biomarkers for assessment of pharmacologic activity for a vascular endothelial growth factor (VEGF) receptor inhibitor, PTK787/ZK 222584 (PTK/ZK): translation of biological activity in a mouse melanoma metastasis model to phase I studies in patients with advanced colorectal cancer with liver metastases.
8/2005PTK787/ZK222584, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, reduces uptake of the contrast agent GdDOTA by murine orthotopic B16/BL6 melanoma tumours and inhibits their growth in vivo.
6/2005The antitumor and antiangiogenic activity of vascular endothelial growth factor receptor inhibition is potentiated by ErbB1 blockade.
3/2004Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown:


Christian Schnell Research Topics

Disease

22Neoplasms (Cancer)
01/2022 - 03/2004
8Melanoma (Melanoma, Malignant)
01/2016 - 08/2005
4Neoplasm Metastasis (Metastasis)
03/2008 - 08/2005
2Huntington Disease (Huntington's Disease)
01/2021 - 11/2016
2Breast Neoplasms (Breast Cancer)
07/2014 - 12/2009
2Colorectal Neoplasms (Colorectal Cancer)
06/2006 - 03/2004
1Schizophrenia (Dementia Praecox)
11/2016
1Alzheimer Disease (Alzheimer's Disease)
11/2016
1Parkinson Disease (Parkinson's Disease)
11/2016
1Pathologic Neovascularization
12/2011
1Acidosis
12/2011
1Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
12/2010
1Vascular Remodeling
09/2010
1Proteinuria
11/2009
1Hypertension (High Blood Pressure)
11/2009
1Body Weight (Weight, Body)
11/2009
1Lymphatic Metastasis
03/2008
1Necrosis
11/2005
1Leukemia
03/2004
1Inflammation (Inflammations)
09/2002
1Infections
09/2002
1Pneumococcal Meningitis (Streptococcus pneumoniae Meningitis)
09/2002

Drug/Important Bio-Agent (IBA)

9Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2016 - 03/2004
5Pharmaceutical PreparationsIBA
11/2016 - 03/2004
5Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
03/2008 - 03/2004
5vatalanib (PTK787)IBA
03/2008 - 03/2004
4Tyrosine Kinase InhibitorsIBA
03/2008 - 03/2004
3Phosphatidylinositols (Phosphatidylinositol)IBA
01/2022 - 04/2009
3dactolisibIBA
12/2009 - 07/2008
2Biological ProductsIBA
02/2012 - 06/2006
2LigandsIBA
09/2010 - 03/2008
2TOR Serine-Threonine KinasesIBA
04/2009 - 07/2008
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
04/2009 - 07/2008
2Biomarkers (Surrogate Marker)IBA
06/2006 - 11/2005
2Phosphotransferases (Kinase)IBA
06/2005 - 03/2004
1JDQ443IBA
01/2022
1Glucose (Dextrose)FDA LinkGeneric
01/2019
1CLR457IBA
01/2019
1Somatomedin Receptors (Somatomedin Receptor)IBA
01/2016
1benthiocarb (Bolero)IBA
07/2014
1Trastuzumab (Herceptin)FDA Link
07/2014
1AlpelisibIBA
05/2014
1NVP-BKM120IBA
02/2012
1Protons (Proton)IBA
12/2011
1EverolimusFDA Link
01/2011
1Dexamethasone (Maxidex)FDA LinkGeneric
11/2009
1Cystatin CIBA
11/2009
1N 30IBA
11/2009
1Mitogen-Activated Protein KinasesIBA
04/2009
1MTOR InhibitorsIBA
04/2009
1Mechanistic Target of Rapamycin Complex 1IBA
04/2009
1ZSTK474IBA
04/2009
1Cyclin D1IBA
04/2009
1Sirolimus (Rapamycin)FDA Link
04/2009
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
04/2009
1Cytotoxins (Cytolysins)IBA
02/2009
1Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
03/2008
1Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
03/2008
1PlatinumIBA
03/2008
1Blocking AntibodiesIBA
03/2008
1Fingolimod Hydrochloride (FTY720)FDA Link
01/2006
1Sphingosine-1-Phosphate ReceptorsIBA
01/2006
1Excipients (Suspending Agents)IBA
11/2005
1epothilone B (EPO906)IBA
11/2005
1Contrast MediaIBA
08/2005
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2005
1gadoterate meglumineIBA
08/2005
1ferumoxides (Feridex)FDA Link
08/2005
1PKI 166IBA
06/2005
1Gefitinib (Iressa)FDA Link
06/2005
1ErbB Receptors (EGF Receptor)IBA
06/2005
1tyrosine receptor (receptor, tyrosine)IBA
06/2005
1Imatinib Mesylate (Gleevec)FDA Link
03/2004
1Bevacizumab (Avastin)FDA Link
03/2004
1Monoclonal AntibodiesIBA
03/2004
1LuciferasesIBA
09/2002
1Toll-Like Receptors (Toll-Like Receptor)IBA
09/2002

Therapy/Procedure

9Therapeutics
01/2021 - 03/2004
1Drug Therapy (Chemotherapy)
03/2008
1Aftercare (After-Treatment)
11/2005